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Saya Takagi (高城 沙耶, Takagi Saya?)is one of the main characters in Highschool of the Dead. Saya is a genius, and her high level of intellect is her major contribution to the group, though it often causes her to be stubborn and arrogant. She usually stays out of combat, preferring to think of strategies to help the others fight. In the anime, Saya is voiced by Eri Kitamura.

Saya first made her escape with fellow classmate Kohta Hirano. She is the daughter of an influential Uyoku dantai politician and her family is deeply involved in Japan's politics. A self-proclaimed genius, Saya's knowledge and deductive capabilities have allowed the group to escape from harm on multiple occasions. She was the first to conclude that "they" respond only to sound. Despite coming from a prestigious family, she despises her parents whom she thought had given up on her in the crisis. It was before their escape from the mansion that she managed to make up with her parents. Other than Rei, she is the only one who has a history with Takashi Komuro since they were children and is hinted to having deeper feelings for him, though she denies this. Slightly self-conscious, she detests the fact that people neither address her by her first name nor look her in the eyes while speaking. The only exception to this is Kohta, with whom she has a strange friendship. Saya has grown very attached to Alice and acts like a mother figure during the crisis. She does her best to keep Alice's innocence intact and will severely scold anyone who would dare attempt to tarnish that to any degree.