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The last of a long line of doctors, Takani Megumi was orphaned as a child when her family left her behind to help those wounded during the Ishin Shishi's siege of Wakamatsu Castle in Aizu. Years later, as a young woman, Megumi was apprenticed by a doctor who taught her how to make opium, telling her that she was making medicine to help people. After the doctor was killed by a merchant named Takeda Kanryuu, Megumi found out that the medicine she had been making was a highly addictive drug that Kanryuu had been selling on the black market. From that day on, she was imprisoned by Kanryuu and forced to make opium for him. One day, she managed to escape and found a small swordsman with red hair to help her.