Yurie is a petite, shy, and otherwise ordinary middle-school girl who suddenly discovers that, overnight, she has become a kami (神), a god in the Shinto sense. She has no idea what kind of god she is or what her powers are. Her friends give her the nickname Kamichu, a portmanteau of kami (god) and chūgakusei (middle school student). In her journey she meets many gods and learns the ways of the gods in order to become a great god herself. During the course of the series, Yurie grows more in being a better god, but she also grows as a person.
Kamichu! is set in the city of Onomichi in Hiroshima prefecture, on the shores of Japan's Inland Sea. Many of the temples and landmarks shown in the anime are real places in and around the city, faithfully depicted. It is set in the Spring of 1983 to Spring of 1984.