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Saeko Busujima (毒島 冴子, Busujima Saeko) is one of the main characters in Highschool of the Dead. She is a student at Fujimi High School and a member of the survivor group led by Takashi Komuro. In the group, Saeko is considered the most reliable of all fighters, and everyone can count on her combat skills to pull them through a tough spot if need be. Like Rei, Saeko is an athletic fighter and talented combat specialist who's forte is in melee battles and can be counted on amongst the many reasons why the protagonists have managed to survive as far as they have. At the beginning of the series, she used a wooden bokken (wooden sword) that she could use very well to fight "them", but she was later given a sword by Souichiro Takagi to fight "them" with.

Saeko is a third-year in high school and president of Fujimi High School's kendo club. She is extremely skilled with a sword and close combat. Not much is known about her family except that her father had traveled abroad on a self-defense conference before the advent of the Outbreak. It is also mentioned in the manga that the Busujima family has been protecting the throne for ages, therefore all Busujima members are skilled in combat.